本文叙述了目前所发现的各种抗生素在接触细菌并停止使用后都有其抗生素的后效应,而且不同的抗生素及细菌之间其后效应明显不同。研究显示:抗生素后效应持续时间的长短可能反映了药物与其作用靶位的占领程度及亲和力,即反应了细菌新合成酶或核蛋白酶所需的时间。对其深入的研究和探讨,不仅可指导合理制定抗生素的给药方案,改善传统的给药方法,同时可减少药物的毒副反应,降低病人的医疗费用。 This article describes the bactericidal effects of the various antibiotics that have been discovered so far after they have been exposed to bacteria and stopped using them, and the subsequent effects between different antibiotics and bacteria are significantly different. Studies have shown that the duration of the post-antibiotic effect may reflect the degree of occupancy and affinity of the drug to its target site, ie, the time required to respond to the bacterial neo-synthetase or nucleoprotease. In-depth research and discussion can not only guide the rational formulation of antibiotic dosing regimen, improve the traditional method of administration, but also reduce the side effects of drugs and reduce the patient’s medical costs.