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理想的化疗方法是能直接和连续给瘤组织高浓度抗癌剂,使其发挥最大的瘤细胞杀灭效应而无其它器官不良作用。雾化化疗就是以此为目标而开创的一种新方法。该法通过口腔和支气管树吸入抗癌剂雾化微粒治疗肺癌,作者1983年研究发现高度有效。现进一步探讨其治疗学价值及作用机理。 该法是将5-Fu和祛痰剂混合制成吸入剂,超声雾化后经呼吸器吸入体内。 18只杂种狗试验表明,狗气管壁、肺门支
The ideal chemotherapy method is to directly and continuously give a high concentration of anti-cancer agents to the tumor tissue, so that it exerts the maximum tumor cell killing effect without other organ adverse effects. Nebulized chemotherapy is a new method that has been pioneered by this goal. The method uses oral and bronchial tree inhalation of atomized microparticles of anti-cancer agents to treat lung cancer. The author’s 1983 study found it to be highly effective. The therapeutic value and mechanism of action are further explored. The method consists of mixing 5-Fu and an expectorant into an inhaler, which is atomized into the body through a respirator after ultrasonic atomization. 18 mongrel dogs tested showed that the dog tracheal wall and hilum branch