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目的研究白细胞介素-1β(IL-1β)和白细胞介素-6(IL-6)致痫过程中谷氨酸(Glu)和γ-氨基丁酸(GABA)在大脑皮质及海马内表达的变化,探讨IL-1β及IL-6在癫痫发病中的作用机制。方法大鼠随机分为生理盐水对照组I、L-1β组I、L-6组,侧脑室注射相应试剂120 min后观察大鼠行为变化,并采用免疫组织化学方法检测大脑皮质及海马内Glu及GABA的表达变化。结果动物行为学观察,生理盐水对照组无明显癫痫发作,IL-1β组I、L-6组发作程度达中度。免疫组织化学染色显示,在注射IL-1β或IL-6 120 min后,IL-1βI、L-6组Glu表达在大脑皮质及海马较对照组明显升高,GABA表达较对照组明显降低,差异显著。结论IL-1β或IL-6可能通过升高Glu含量并降低γ-氨基丁酸的含量参与促痫和致痫过程,从而使神经元兴奋性升高促进癫痫发作。
Objective To investigate the changes of glutamate (Glu) and γ-aminobutyric acid (GABA) expression in cerebral cortex and hippocampus during the epilepsy induced by interleukin-1β (IL-1β) and interleukin-6 , To explore the mechanism of IL-1β and IL-6 in the pathogenesis of epilepsy. Methods The rats were randomly divided into saline control group I, L-1β group I, L-6 group, the lateral ventricle injection of the corresponding reagents for 120 min after the change in behavior was observed, and immunohistochemistry was used to detect cerebral cortex and hippocampal Glu And GABA expression changes. Results Animal behavior observation, saline control group without obvious seizures, IL-1β group I, L-6 group degree of attack was moderate. Immunohistochemical staining showed that the expression of Glu in IL-1βI and L-6 groups was significantly increased in cerebral cortex and hippocampus compared with the control group after injection of IL-1β or IL-6 for 120 min, the GABA expression was significantly lower than the control group, the difference Significant. Conclusion IL-1β or IL-6 may participate in the processes of epileptogenesis and epileptogenesis by increasing the content of Glu and decreasing the content of γ-aminobutyric acid, thus increasing the excitability of neurons and promoting the seizure.