ｐ５３基因突变是人类肿瘤中最常见的突发之一，胶质瘤约有１／３发生ｐ５３基因突变。通过对胶质瘤ｐ５３基因突变和蛋白表达的研究，提出了多形性胶质母细胞瘤的三种不同起源方式，发现ｐ５３蛋白表达在脑胶质瘤与反应性胶质增生的鉴别诊断中有一定的作用，但多数资料的研究结果提示ｐ５３蛋白表达对脑胶质瘤患者的预后判断无意义。 p53 gene mutation is one of the most common human tumors in the sudden onset of glioma about 1/3 mutations in p53 gene. Through the study of p53 gene mutation and protein expression in gliomas, three different origins of glioblastoma multiforme have been proposed, and p53 protein expression has been found in the differential diagnosis between glioma and reactive glia However, most of the data suggest that p53 protein expression is not meaningful for the prognosis of patients with glioma.