论文部分内容阅读
近年来对高原缺氧机制的分子生物学水平研究较为多的是氧自由基,其过氧化和抗氧化过程所涉及的物质和多种血氧代谢酶-腺苷酸(aden-osine monophosphate,AMP)、谷胱甘肽(glutathi-one,GSH)、谷胱甘肽过氧化物酶(glutathione peri-oxidase,GSH-PX)、丙二醛(malonaldehyde,MDA)、过氧化氢酶(Catalase,CAT)、过氧化物歧化酶(superoxide dismutase,SOD)在高原医学的各项研究活动中具有很重要的意义。本文综述氧自由基学说和高原缺氧机制之间的关系,尝试从细胞凋亡学说加以解释,同时综述了高原习服和适应的“线粒体适应”学说(Mitochondrial adaptation)。
In recent years, the molecular biology of plateau hypoxia mechanism is more oxygen free radicals, its peroxidation and antioxidant processes involved in a variety of substances and a variety of blood oxygen metabolism enzyme - adenosine (adenosine) (AMP Glutathione peroxidase (GSH), glutathione peroxidase (GSH-PX), malonaldehyde (MDA), catalase (CAT) ), Superoxide dismutase (SOD) plays an important role in the research activities of plateau medicine. This paper reviews the relationship between the oxygen free radical theory and the mechanism of plateau hypoxia, attempts to explain it from the theory of apoptosis, and reviews Mitochondrial adaptation of plateau acclimatization and adaptation.