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目的探讨脾部分切除术和部分脾栓塞术对门脉高压症患者免疫功能的影响。方法观察18例脾部分切除术和16例部分脾栓塞术治疗肝硬化脾亢术后不同时期外周血免疫球蛋白、T淋巴细胞分化抗原(CD3、CD4、CD8)的变化,以及两组患者手术前后红细胞、白细胞、血小板计数的变化。结果脾部分切除术和部分脾栓塞术后CD3、CD4、CD8无明显变化。两组患者手术后红细胞、白细胞、血小板计数均达到正常指标。结论脾脏大部切除术与部分脾栓塞术治疗PHT在对机体免疫功能的影响以及提高红细胞、白细胞、血小板记数方面大致是一致的。
Objective To investigate the effect of partial splenectomy and partial splenic embolization on immune function in patients with portal hypertension. Methods 18 cases of partial splenectomy and 16 cases of partial splenic embolization were used to observe the changes of peripheral blood immunoglobulin, T lymphocyte differentiation antigen (CD3, CD4, CD8) in patients with cirrhosis and hypersplenism, Before and after the red blood cells, white blood cells, platelet count changes. Results There was no significant change of CD3, CD4, CD8 after partial splenectomy and partial splenic embolization. Two groups of patients after surgery, red blood cells, white blood cells, platelet count reached the normal indicators. Conclusion The treatment of PHT with partial splenic resection and partial splenic embolization is roughly the same as the effect of PHT on the immune function and the increase of erythrocyte, leukocyte and platelet counts.