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目的:建立维甲酸软膏的质量控制方法。方法:高效液相色谱法对维甲酸软膏进行含量测定。结果:维甲酸在2～50μg·ml~(-1)范围内线性关系良好(r=0.999 7),平均回收率为99.7%,RSD为1.2%。结论:该方法简便、快速、准确,可作为维甲酸软膏的质量控制。
Objective: To establish a quality control method of retinoic acid ointment. Methods: The content of retinoic acid ointment was determined by high performance liquid chromatography. RESULTS: Retinoic acid showed good linearity (r = 0.999 7) in the range of 2 ~ 50μg · ml ~ (-1) with an average recovery of 99.7% and a RSD of 1.2%. Conclusion: The method is simple, rapid and accurate and can be used as quality control of retinoic acid ointment.