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目的调查HIV流行地区庚型肝炎病毒(HGV)在HIV阳性人群中的感染率,并探讨其对HIV病程的影响。方法根据已知并公认的HGV序列,设计特异巢式引物,建立HGVRNA的巢式RT-PCR方法,对100例HIV-1阳性感染者进行检测,同时进行CD4+T细胞计数和HIV病毒载量的测定。结果 100例HIV-1阳性者中检测出HGVRNA阳性感染者22例(22%);合并感染HGV的HIV感染人群体内可见有较高CD4细胞数。结论 HIV阳性感染者有较高的HGV重叠感染率,可能与其具有共同的传播途径有关,合并感染HGV似乎能延缓HIV感染者的病程。
Objective To investigate the prevalence of hepatitis G virus (HGV) in HIV-positive population in endemic areas of HIV and to explore its impact on the course of HIV. Methods Based on the known and recognized HGV sequences, a specific nested primer was designed and a nested RT-PCR method was established to detect 100 HIV-1 positive patients. CD4 + T cell count and HIV viral load The determination. Results Totally 22 (22%) HGV RNA positive cases were detected in 100 cases of HIV-1 positive patients. The number of CD4 cells in HIV-infected patients with HGV infection was higher than that in other groups. Conclusions HIV-positive patients have a higher prevalence of HGV infection, which may be related to their common transmission route. Combined infection of HGV seems to delay the course of HIV-infected patients.