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A novel and efficient method for the preparation of nucleoside 5’-tetraphosphates has been developed by coupling nucleoside 5’-phosphoropiperidates with triphosphate reagent in the presence of 4,5-dicyanoimidazole(DCI) activator.Further coupling of the nucleoside 5’-tetraphosphates with nucleoside 5’-phosphoropiperidates via the P(V)-N activation strategy provided a reliable synthetic method for both symmetrical and asymmetrical dinucleoside pentaphosphates.
A novel and efficient method for the preparation of nucleoside 5’-tetraphosphates has been developed by coupling nucleoside 5’-phosphoropiperidates with triphosphate reagent in the presence of 4,5-dicyanoimidazole (DCI) activator. Thermal coupling of the nucleoside 5’-tetraphosphates with nucleoside 5’-phosphoropiperidates via the P (V) -N activation strategy provided a reliable synthetic method for both symmetrical and asymmetrical dinucleoside pentaphosphates.