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目的:观察冠心病患者血清中尿酸、高敏C反应蛋白、纤维蛋白原水平的变化。方法:选取2010年11月至2011年11月于我院就诊的68例冠心病患者(稳定型心绞痛21例,不稳定型心绞痛24例,急性心肌梗死13例)作为研究对象,并选取同期于我院体检中心体检的62例健康人为对照组,检测受试者血清中尿酸、高敏C反应蛋白、纤维蛋白原的水平。结果:研究组患者血清中UA、CRP和FBG水平显著高于对照组(P<0.05)。与稳定型心绞痛组比,不稳定型心绞痛的CRP水平增高(5.34±1.98 mg/L vs.11.36±2.73 mg/L,P<0.05),急性心肌梗死组的UA(345.63±86.4μmol/L vs.493.76±101.2μmol/L,P<0.05)、CRP(5.34±1.98mg/L vs.21.3±2.24 mg/L,P<0.05)和FBG(3.86±1.34 g/L vs.6.85±2.36 g/L,P<0.05)水平显著增高,与不稳定型心绞痛组比,急性心肌梗死组的UA(378.91±89.7μmol/L vs.493.76±101.2μmol/L,P<0.05)、CRP(11.36±2.73 mg/L vs.21.3±2.24 mg/L,P<0.05)和FBG(4.27±2.08 g/L vs.6.85±2.36 g/L,P<0.05)水平显著增高(P<0.05)。结论:冠心病患者血清中尿酸、高敏C反应蛋白和纤维蛋白原的水平升高,3个指标可用于评估治疗效果和预后。
Objective: To observe the changes of serum uric acid, high-sensitivity C-reactive protein and fibrinogen in patients with coronary heart disease. Methods: Sixty-eight patients with coronary heart disease (21 cases of stable angina pectoris, 24 cases of unstable angina pectoris and 13 cases of acute myocardial infarction) who were treated in our hospital from November 2010 to November 2011 were enrolled in this study. Sixty-two healthy subjects in the physical examination center of our hospital were the control group, and the levels of uric acid, high-sensitivity C-reactive protein and fibrinogen in the serum of the subjects were detected. Results: The levels of serum UA, CRP and FBG in the study group were significantly higher than those in the control group (P <0.05). Compared with patients with stable angina pectoris, CRP levels in patients with unstable angina pectoris increased (5.34 ± 1.98 mg / L vs.11.36 ± 2.73 mg / L, P <0.05), and UA in acute myocardial infarction patients (345.63 ± 86.4μmol / L vs .493.76 ± 101.2μmol / L, P <0.05), CRP (5.34 ± 1.98mg / L vs.21.3 ± 2.24mg / L, P <0.05) and FBG (3.86 ± 1.34g / L vs.6.85 ± 2.36g / L, P <0.05). Compared with unstable angina pectoris group, the levels of UA (378.91 ± 89.7μmol / L vs.493.76 ± 101.2μmol / L, P <0.05) and CRP (11.36 ± 2.73 (P <0.05) and the level of FBG (4.27 ± 2.08 g / L vs.6.85 ± 2.36 g / L, P <0.05) was significantly higher than that of the control group (mg / L vs.21.3 ± 2.24 mg / L, P <0.05). Conclusion: Serum levels of uric acid, high-sensitivity C-reactive protein and fibrinogen are elevated in patients with coronary heart disease. Three indicators can be used to evaluate the therapeutic effect and prognosis.