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目的比较两种囊腔人工皱缩(AS)预处理方法在人囊胚玻璃化冻融中的应用效果。方法囊胚玻璃化冷冻复苏患者564例分为两组:A组201例,采用注射针抽穿AS法;B组363例,采用激光打孔AS法。比较两组的相关结果。结果 A组平均移植囊胚数(1.72±0.67)个,B组平均移植囊胚数(1.72±0.52)个;A、B组冷冻囊胚复苏后的存活率和孵出率分别为92.1%和79.0%、94.6%和79.6%,A组和B组玻璃化冻融移植后临床妊娠率、种植率、活产率、流产率分别为51.8%、38.4%、42.4%、18.2%和56.4%、43.2%、46.7%、16.3%,两组在以上各指标间均无统计学差异(P>0.05)。结论两种囊腔AS法均是有效的预处理方法,激光打孔AS法效果可能稍好一些。
Objective To compare the effects of two methods of preconditioning with artificial folds (AS) on the vitrification and freezing of human blastocysts. Methods 564 cases of blastocyst vitrification were divided into two groups: 201 cases in group A were treated with needle aspiration AS method; group B with 363 cases were treated by laser drilling AS method. The results of the two groups were compared. Results The mean number of blastocysts in group A was 1.72 ± 0.67, and the number of blastocysts in group B was 1.72 ± 0.52. The survival rate and hatching rate of group A and B after resuscitation were 92.1% and 79.0%, 94.6% and 79.6% respectively. The clinical pregnancy rate, implantation rate, live birth rate and abortion rate in group A and B after vitrification were 51.8%, 38.4%, 42.4%, 18.2% and 56.4% 43.2%, 46.7% and 16.3% respectively. There was no significant difference between the above indexes (P> 0.05). Conclusion Both AS methods are effective pretreatment methods and the laser drilling AS method may be slightly better.