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目的探究血清肿瘤标志物在肺癌患者辅助诊断中的临床应用。方法 56例肺癌患者作为病例组,以同期来本院体检的60例健康人作为对照组。对两组血清中的癌胚抗原(CEA)、甲胎蛋白(AFP)、糖类抗原(CA)153、CA199、CA125指标水平进行检测,观察检测结果。结果病例组CA199、AFP水平与对照组比较,差异无统计学意义(P>0.05),CEA、CA153、CA125与对照组比较,差异有统计学意义(P<0.05)。CEA、CA153、CA125三项联合诊断的特异性和灵敏度与单项诊断比较,差异具有统计学意义(P<0.05),且三项联合诊断的结果中,特异性和灵敏度要高于单项指标的检测。结论 CEA、CA153、CA125三个肿瘤标志物均可作为诊断肺癌的血清指标,联合诊断可以提高肺癌诊断的灵敏度和特异性,有助于肺癌的早期诊断。
Objective To investigate the clinical application of serum tumor markers in the diagnosis of lung cancer. Methods Fifty-six patients with lung cancer were selected as the case group and 60 healthy people in our hospital during the same period as the control group. The levels of carcinoembryonic antigen (CEA), AFP, carbohydrate antigen (CA) 153, CA199 and CA125 in the two groups were detected and the test results were observed. Results The levels of CA199 and AFP in case group were not significantly different from those in control group (P> 0.05). There was significant difference between CEA, CA153 and CA125 group and control group (P <0.05). The specificity and sensitivity of the three combined diagnosis of CEA, CA153 and CA125 were significantly different from those of single diagnosis (P <0.05), and the specificity and sensitivity of the three combined diagnosis were higher than those of single index . Conclusion The three tumor markers CEA, CA153 and CA125 can be used as serum markers in the diagnosis of lung cancer. Combined diagnosis can improve the sensitivity and specificity of lung cancer diagnosis and contribute to the early diagnosis of lung cancer.