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目的探讨氟西汀对卒中后抑郁的临床治疗效果。方法选择2012年1月至2014年9月卒中后抑郁患者87例,随机分为对照组(43例,给予常规治疗加心理疏导)和观察组(44例,加用氟西汀),比较两组治疗前后汉密尔顿抑郁量表(HAMD)、简易智能精神状态检查量表(MMSE)评分、Barthel指数评分及脑卒中患者生存质量综合评定问卷(GQOLI)评分。结果治疗4、8周后,观察组HAMD、MMSE评分均优于对照组;治疗8周后患者Barthel指数评分及GQOLI评分均优于对照组,差异有统计学意义(P<0.05)。结论卒中后抑郁患者治疗中应用氟西汀可有效改善患者抑郁症状及精神状态,值得临床推广应用。
Objective To investigate the clinical effect of fluoxetine on post-stroke depression. Methods Eighty-seven patients with post-stroke depression from January 2012 to September 2014 were randomly divided into control group (43 cases treated with conventional therapy plus psychological grooming) and observation group (44 cases treated with fluoxetine) The Hamilton Depression Inventory (HAMD), Mini-Mental State Examination Scale (MMSE), Barthel Index, and GQOLI scores of the patients before and after treatment were measured. Results After 4 and 8 weeks of treatment, the HAMD and MMSE scores of the observation group were better than those of the control group. The Barthel index and GQOLI score of the observation group were better than those of the control group after 8 weeks of treatment (P <0.05). Conclusions Fluoxetine can effectively improve depression symptoms and mental state in patients with post-stroke depression, which is worthy of clinical application.