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目的:比较银翘散不同提取物(水提和醇提)的体内抗流感病毒作用。方法:以甲型流感病毒FM1鼠肺适应株滴鼻感染NIH小鼠,造成病毒性肺炎,观察银翘散水提物及其大孔树脂洗脱物、醇提取物等治疗组和病毒对照组的生存状态及检测肺指数。结果:银翘散水提物中剂量[300mg/(kg·d)]可以一定程度减轻小鼠感染流感病毒引起的体重减轻等全身症状,降低因发生病毒性肺炎升高的肺指数,改善鼠肺间质性肺炎的病变,肺指数差异有显著性意义(P<0.05),银翘散水提物和银翘散醇提物组[500mg/(kg·d)]未显示有体内抑制病毒性肺炎效果。结论:银翘散水提物具有体内抗流感病毒作用,在小鼠模型中同等剂量下较乙醇提取物及基于水提物再精制的水洗脱部位效果更明显。
Objective: To compare the anti-influenza virus effects of different extracts of Yinqiao Powder (water extraction and alcohol extraction). Methods: Infectious NIH mice were intranasally infected with influenza A virus FM1 rat lung-adapted strain to induce viral pneumonia. The effects of water extract of macroporous resin and macroporous resin eluate and alcohol extract and viral control group were observed Survival status and detection of lung index. Results: The medium dose [300mg / (kg · d)] of Yinqiaosan water extract can reduce systemic symptoms such as body weight loss induced by influenza virus in mice to a certain extent, reduce lung index caused by viral pneumonia, improve rat lung Interstitial pneumonia lesions, lung index differences were significant (P <0.05), Yinqiao powder and Yinqiao powder group [500mg / (kg · d)] showed no in vivo inhibition of viral pneumonia effect. Conclusion: The water extract of Yinqiao Powder has anti-influenza virus activity in vivo. Compared with the ethanol extract and the water-eluting residue re-refined based on water extract, the effect of the extract from Yinqiao Powder is more obvious in the mouse model.