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目的探讨雷公藤多甙联合泼尼松治疗成人过敏性紫癜性肾炎(HSPN)的效果和安全性。方法选取60例明确诊断为HSPN的成人患者,随机分2组,观察组30例,采用雷公藤多甙联合泼尼松治疗,对照组常规激素治疗。治疗6个月观察疗效,追踪24h尿蛋白定量,血白蛋白等指标。也记录不良反应。结果治疗6个月后观察组尿蛋白较治疗前明显下降,差异有统计学意义(P<0.05)。两组治疗后比较差异有统计学意义(P<0.05)。治疗6个月后观察组血白蛋白较治疗前明显升高(P<0.05)。两组治疗后比较差异有统计学意义(P<0.05)。治疗组总有效率明显高于对照组(P<0.05)。两组未见严重不良反应发生。结论雷公藤多苷联合泼尼松治疗HSPN可有效降低尿蛋白,延缓紫癜性肾炎发展,疗效明显且安全可靠。
Objective To investigate the efficacy and safety of tripterygium glycosides combined with prednisone in the treatment of adult allergic purpura nephritis (HSPN). Methods Sixty adult patients with definite diagnosis of HSPN were randomly divided into two groups. The observation group consisted of 30 patients. The patients were treated with tripterygium glycosides combined with prednisone and the control group with conventional hormone therapy. Treatment of 6 months to observe the efficacy of tracking 24h urinary protein, serum albumin and other indicators. Adverse reactions were also recorded. Results After 6 months of treatment, urinary protein in the observation group decreased significantly compared with that before treatment, with significant difference (P <0.05). The difference between the two groups after treatment was statistically significant (P <0.05). After 6 months of treatment, serum albumin in observation group was significantly higher than that before treatment (P <0.05). The difference between the two groups after treatment was statistically significant (P <0.05). The total effective rate in the treatment group was significantly higher than that in the control group (P <0.05). No serious adverse reactions occurred in both groups. Conclusion Tripterygium glycosides combined with prednisone treatment of HSPN can effectively reduce urinary protein, delay the development of purpura nephritis, the effect is obvious and safe and reliable.