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观察AngⅡ受体拮抗剂对DN患者血浆ET水平的影响。用RIA法测定正常对照组、DN患者用Losartan治疗前后的血浆ET浓度并检测与DN诊治有关的各项指标。DN患者经Losartan治疗后血浆ET明显降低 ,但水平仍显著高于正常对照组。⑴Losartan治疗可使DN患者血浆ET浓度降低 ,并与血糖、血压、蛋白尿、肾功能改善呈正相关 ;⑵ 6～ 8周的Losartan治疗不能使患者血浆ET恢复正常水平 ,提示DN病理生理过程及影响因素十分复杂。
To observe the effect of AngⅡreceptor antagonist on plasma ET level in patients with DN. RIA method was used to determine the plasma concentration of ET in normal control group and DN patients before and after treatment with Losartan and to detect the indexes related to the diagnosis and treatment of DN. After treatment with Losartan, the plasma ET was significantly lower in DN patients, but the level was still significantly higher than that in normal controls. ⑴Losartan treatment can reduce the concentration of plasma ET in patients with DN, and with blood glucose, blood pressure, proteinuria, renal function improvement was positively correlated; ⑵ 6 to 8 weeks of Losartan treatment can not make patients with plasma ET returned to normal levels, suggesting that DN pathophysiology and impact The factors are complex.