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为评价抑制排卵和生育,对5种不同释放率的3-酮地索高诺酮(3-酮DSG)皮下埋植剂的临床应用进行研究。 3-酮DSG是DSG有生物活性的代谢产物,有较弱的雄激素及合成代谢活性和较强的抗雌激素(E)活性,无E、盐皮质激素活性,对脂蛋白影响很小。由于其高效、可经单一硅胶埋植释放低剂量而起抑制生育作用,因此适用于埋植剂避孕。由美国人口理事会(PC)提供长度为1、2和4cm三种硅橡胶埋植剂,体内释放率分别为10、20和40μg/日;荷兰Organon(ORG)提供长度2.4和4.4cm两种EvA共聚物埋植剂,释放率为15和30μg/日。受试看为有生育力,18～35岁,月经规
To evaluate ovulation suppression and fertility, 5 different release rates of 3-ketosalpinostat (3-keto DSG) were studied. 3-keto DSG is a biologically active metabolite of DSG. It has weaker androgens and anabolic activities and strong anti-estrogen (E) activity. It has no E and mineralocorticoid activity and has little effect on lipoproteins. Because of its high efficiency, it can inhibit the fertility by implanting a single dose of low-dose silicone implant, so it is suitable for contraception of implants. Three Silicone Implants of 1, 2 and 4 cm in length were provided by the Population Council of the United States (PC) with in vivo release rates of 10, 20 and 40 μg / day, respectively. Organon (ORG) of the Netherlands provided both 2.4 and 4.4 cm lengths EvA copolymer implants with release rates of 15 and 30 μg / day. Subjects considered fertile, 18 to 35 years old, menstrual rules