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随着人们生活方式的改变以及前列腺特异性抗原筛查的普及,前列腺癌的诊断和治疗更为重要。尽管内分泌治疗对于进展性前列腺癌有治疗效果,但最终会进展为去势抵抗性前列腺癌,从而严重影响患者的生存期。近年来,研究者对于去势抵抗性前列腺癌的治疗做出了巨大努力,包括新的内分泌治疗、细胞毒性的化学治疗、免疫治疗以及以骨转移为靶点的治疗方式逐步问世,本文就这些新的治疗进展进行综述,以期为临床医生及进展性前列腺癌患者提供更多的治疗选择,延长总体生存期,提高生活质量。
As people’s lifestyle changes and the popularity of prostate-specific antigen screening, the diagnosis and treatment of prostate cancer is even more important. Although endocrine therapy has a therapeutic effect on progressive prostate cancer, it eventually progresses to castration-resistant prostate cancer, which seriously affects the survival of the patient. In recent years, researchers have made great efforts in the treatment of castrate-resistant prostate cancer, including new endocrine therapy, cytotoxic chemotherapy, immunotherapy and bone metastasis as the target of treatment gradually come out, this article The progress of the new treatment is reviewed in order to provide clinicians and patients with advanced prostate cancer with more treatment options, to extend the overall survival and improve the quality of life.