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目的调查川东北地区健康人群血清鳞状细胞癌相关抗原(SCC-Ag)浓度,建立适合川东北地区健康人群血清SCC-Ag的参考值范围。方法收集体格检查和相关的实验室检查均无异常的表面健康人群3 252例,按性别和年龄分组,采用化学发光法检测其血清SCC-Ag的含量,并对所得数据进行统计学处理。结果 3 252例健康人群血清SCC-Ag含量为(0.60±0.30)ng/ml;健康男性血清SCC-Ag浓度为(0.70±0.30)ng/ml,高于女性血清中SCC-Ag水平(0.50±0.3)ng/ml,差异有统计学意义(Z=-17.194,P=0.000);健康男性、女性血清SCC-Ag水平与年龄无关,其差异无统计学意义(χ~2=7.91,P=0.161;χ~2=8.707,P=0.121)。健康人群血清SCC-Ag参考范围在男性为0.00~1.30 ng/ml,女性为0.00~1.00 ng/ml。结论川东北地区健康人群血清SCC-Ag的参考值范围应根据性别分别设定。
Objective To investigate the concentration of SCC-Ag in healthy population in northeastern Sichuan and establish the reference value range of SCC-Ag for healthy population in northeastern Sichuan. Methods A total of 3 252 healthy people with no abnormal surface health status were collected by physical examination and related laboratory tests. The levels of SCC-Ag in serum were detected by chemiluminescence method after treatment according to sex and age. The data were statistically analyzed. Results Serum levels of SCC-Ag were (0.60 ± 0.30) ng / ml in 3 252 healthy subjects and 0.70 ± 0.30 ng / ml in healthy males (0.50 ± 0.30) ng / ml 0.3) ng / ml, the difference was statistically significant (Z = -17.194, P = 0.000). Serum levels of SCC-Ag in healthy males and females were not related to age (χ ~ 2 = 7.91, P = 0.161; χ ~ 2 = 8.707, P = 0.121). Serum SCC-Ag reference range was 0.00-1.30 ng / ml in men and 0.00-1.00 ng / ml in females. Conclusion The reference value range of serum SCC-Ag in healthy population in northeastern Sichuan should be set separately according to sex.