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Qa-1(小鼠)和HLA-E(人)是一类非典型MHC-Ib类分子,在活化的T细胞及APC表面表达可暂时上调,与调节性CD8~+T细胞发挥免疫抑制作用密切相关,在免疫应答和免疫调节方面起重要作用。近年来,由于Qa-1限制性调节性CD8~+T细胞的潜在临床应用价值而使对Qa-1分子的研究也越来越受到重视。本文就Qa-1分子的总体特征,与结合肽复合物产生不同效应,与NKG2共同作用对免疫应答的调节及Qa-1限制性调节性CD8~+T细胞在免疫调节中的研究进展作一综述。
Qa-1 (mouse) and HLA-E (human) are a group of atypical MHC class Ib molecules that are transiently upregulated on the surface of activated T cells and APCs and play an immunosuppressive role with regulatory CD8 + T cells Is closely related and plays an important role in immune response and immune regulation. In recent years, more and more attention has been paid to the Qa-1 molecule due to the potential clinical value of Qa-1 restricted regulatory CD8 + T cells. In this paper, the overall characteristics of Qa-1 molecules, binding peptide complexes with different effects, together with NKG2 regulation of immune response and Qa-1 regulatory CD8 ~ + T cells in immunomodulatory research progress in Summary.