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目的:探讨中西医结合疗法对原发性高血压病人颈动脉内膜-中层增厚的消退作用。方法:将112例原发性高血压病人随机分为两组。治疗组56例,对照组56例。两组常规口服替米沙坦,治疗组在此基础上加用中药天麻勾藤饮,两组均治疗24周。比较两组治疗前后的血压、颈动脉内膜-中层厚度(IMT)、TG、TC、LDL-C、HDL-C等的变化。结果:治疗后两组SBP、DBP分别与治疗前比较均有显著性差异(P<0.05),治疗后组间比较无显著性差异(P>0.05)。服药24周后,治疗组颈动脉IMT治疗后与治疗前比较,有非常显著性差异(P<0.01)。两组治疗后比较也有非常显著性差异(P<0.01)。治疗组治疗后TG、TC、LDL-C与治疗前比较有显著差异(P<0.05),对照组治疗前后无明显差异(P>0.05)。结论:口服替米沙坦与中药天麻勾藤饮不但能较好的降压作用,对颈动脉IMT增厚亦有消退作用,同时能够降低TG、TC、LDL-C的水平。
Objective: To explore the effect of traditional Chinese and Western medicine on carotid intima-media thickness in patients with essential hypertension. Methods: 112 cases of essential hypertension were randomly divided into two groups. 56 cases in the treatment group and 56 cases in the control group. Two groups of conventional oral telmisartan, the treatment group based on the use of traditional Chinese medicine Tianma Gouteng drink, both groups were treated for 24 weeks. The changes of blood pressure, carotid artery intima-media thickness (IMT), TG, TC, LDL-C and HDL-C before and after treatment were compared between the two groups. Results: After treatment, the SBP and DBP in both groups were significantly different from those before treatment (P <0.05). There was no significant difference between the two groups after treatment (P> 0.05). After taking the drug for 24 weeks, there was a very significant difference (P <0.01) between the treatment group and the IMT after carotid artery treatment. There was also a significant difference between the two groups after treatment (P <0.01). TG, TC and LDL-C in the treatment group were significantly different from those before treatment (P <0.05), but there was no significant difference in the control group before and after treatment (P> 0.05). Conclusion: Oral telmisartan and traditional Chinese medicine Tianma Goutengyin can not only depress blood pressure, but also attenuate carotid IMT. At the same time, it can lower the levels of TG, TC and LDL-C.