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作者应用PCR技术检测9例慢性乙型肝炎病人经抗病毒治疗或自发性HBsAg阴转3～67个月后血清和肝组织中的HBV DNA。病人初起时均有血清转氨酶持续升高1年以上,有慢性乙型肝炎的组织学特征,血清HBV DNA、HBeAg阳性。7例HBsAg在抗病毒治疗后转阴,2例则为自发转阴。病人在HBsAg转阴后随访3～67个月(平均28个月),随访期转氨酶正常,其中6例并出现抗HBs。
The authors used PCR technology to detect HBV DNA in serum and liver tissue of 9 patients with chronic hepatitis B after antiviral treatment or spontaneous HBsAg conversion from 3 to 67 months. Patients with initial elevated serum aminotransferases continued to rise more than 1 year, with histological features of chronic hepatitis B, serum HBV DNA, HBeAg positive. Seven cases of HBsAg negative after antiviral therapy, 2 cases were spontaneous negative. The patients were followed up for 3 to 67 months (average 28 months) after negative HBsAg, and normal aminotransferases were observed during the follow-up period. Six of them showed anti-HBs.