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氯胺酮自60年代用于临床,由于安全系数大,镇痛效果好,且有升压作用等优点,最初评价很高。随着不良反应的不断出现而限制了广泛的应用。近年来多采用复合麻醉以增强麻醉效果,减少副作用。我科1978～1980年,按不同配方分三组观察了154例氯胺酮复合麻醉手术,以确定合适的配方,有利于临床开展。其中男96例,女58例。平均年龄40(1～74)岁。手术部位有头颅、颌面、颈、胸、腹及四肢脊柱。手术时间为35分钟～11小时。麻醉方法麻醉前用药:成人常规阿托品0.5mg、哌替啶50mg肌注;小儿阿托品0.015mg/kg肌注。6岁以上小儿可加哌替啶1mg/kg肌注。麻醉诱导:成人以2.5%硫贲妥钠12～20ml及琥珀胆硷80～100mg静注,气管插管。小儿以安定0.25～0.3mg/kg静注或以2.5%硫贲妥钠15～20mg/kg肌注。麻醉维持共分三组:第一组为氯胺酮—安定复合麻醉共17例,即10%葡萄糖溶液300ml加入氯胺酮300mg和安定30mg混合液持续静滴。第二组为安定氯胺酮—普鲁卡因复合麻醉共45例,
Ketamine since the 60’s for clinical use, due to safety factor, analgesic effect, and the advantages such as the role of boosting, the initial evaluation of high. With the advent of adverse reactions continue to limit the wide range of applications. In recent years, more use of composite anesthesia to enhance anesthesia, reduce side effects. Our department from 1978 to 1980, divided into three groups according to different formulations were observed in 154 cases of ketamine combined anesthesia in order to determine the appropriate formula is conducive to clinical development. There were 96 males and 58 females. The average age of 40 (1 ~ 74) years old. Surgical sites are head, maxillofacial, neck, chest, abdomen and spine limbs. The operation time is 35 minutes to 11 hours. Anesthesia before anesthesia medication: Adult conventional atropine 0.5mg, meperidine 50mg intramuscular injection; children atropine 0.015mg / kg intramuscular injection. Children over 6 years old can be given pethidine 1mg / kg intramuscular injection. Anesthesia induction: Adults with 2.5% thiopental sodium 12 ~ 20ml and succinylcholine 80 ~ 100mg intravenous intubation. Pediatric diazepam 0.25 ~ 0.3mg / kg intravenously or 2.5% thiopental sodium 15 ~ 20mg / kg intramuscular injection. Anesthesia was divided into three groups: the first group consisted of 17 ketamine-diazepam anesthesia, that is, 300ml of 10% dextrose solution was added with ketamine 300mg and diazepam 30mg for continuous intravenous infusion. The second group for the stability of ketamine - procaine anesthesia a total of 45 cases,