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目的 研究氟与脂质过氧化的关系 ,硒对氟引起的脂质过氧化的影响。方法 将 40只SD大鼠随机分为 4组 ,按对照、氟、硒、硒氟不同饮水饲养 8周 ,观察硒对氟引起大鼠血清、肝、肾、心、睾丸脂质过氧化的影响。结果 与对照组相比 ,加氟组全血谷胱甘肽过氧化物酶 (GSH -Px)显著下降 ,血清、肝、肾、心、睾丸的脂质过氧化 (LPO )含量水平明显升高 ;加硒组增强机体抗氧化功能 ,提高全血GSH -Px活性 ,降低机体LPO含量。结论 可通过补硒来拮抗氟引起的脂质过氧化
Objective To study the relationship between fluoride and lipid peroxidation and the effect of selenium on lipid peroxidation induced by fluoride. Methods Forty Sprague-Dawley rats were randomly divided into four groups and fed with fluoride, selenium and selenium fluoride for 8 weeks. The effects of selenium on lipid peroxidation in serum, liver, kidney, heart and testes were observed . Results Compared with the control group, glutathione peroxidase (GSH-Px) decreased significantly in the fluoride group and the level of lipid peroxidation (LPO) in the serum, liver, kidney, heart and testis was significantly increased ; Selenium group increased body antioxidant function, improve GSH-Px activity of whole blood, reduce the body’s LPO content. Conclusion Selenium supplementation can antagonize lipid peroxidation caused by fluoride