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Snail1基因产物是E-钙粘素表达的转录抑制物,在一些上皮性肿瘤细胞系中则是上皮细胞间质转化(EMT)的诱导因子。当上皮细胞获得间质细胞表型时,Snail1基因会被诱导转录。这项研究提示Snail1蛋白限制自身表达:Snail1蛋白结合到其启动子的E盒(在转录起始点上游146bp处)并抑制其活?
The Snail1 gene product is a transcriptional repressor of E-cadherin expression and is an inducer of epithelial mesenchymal transition (EMT) in some epithelial tumor cell lines. The Snail1 gene is induced to transcribe when epithelial cells acquire a stromal phenotype. This study suggests that Snail1 protein limits self-expression: Snail1 binds to its promoter’s E box (146 bp upstream of the transcriptional start point) and inhibits its activity?