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目的对参苓益胃胶囊的药效学及毒理学进行基础研究。方法采用小鼠胃排空、大鼠慢性胃炎模型观察参苓益胃胶囊对胃的防护作用;观察参苓益胃胶囊对正常大鼠胃液分泌、胃液酸度、胃蛋白酶活性的影响;观察小鼠对参苓益胃胶囊最大耐受量。结果参苓益胃胶囊对小鼠胃排空无影响,可使大鼠胃酸酸度显著回升,胃蛋白酶活性回升。结论参苓益胃胶囊对小鼠胃排空无影响,可使慢性胃炎模型大鼠相应病理指标朝趋于正常值方向呈显著性改善,提示参苓益胃胶囊有治疗慢性胃炎的药理作用,且无明显急性毒性反应。
Objective To study the pharmacodynamics and toxicology of Shenling Yiwei Capsule. Methods Gastric emptying in mice and chronic gastritis model were used to observe the protective effect of Shenling Yiwei Capsule on stomach. The effects of Shenlingyiwei Capsule on gastric juice secretion, gastric juice acidity and pepsin activity were observed. Shenling Yiwei capsules on the maximum tolerance. Results Shenling Yiwei Capsule had no effect on gastric emptying in mice, and gastric acidity of rats significantly increased and pepsin activity rose. Conclusion Shenling Yiwei Capsule had no effect on gastric emptying in mice, which could significantly improve the corresponding pathological indexes of rats with chronic gastritis toward the normal direction, suggesting that Shenlingyiwei Capsule has the pharmacological effects of treating chronic gastritis, And no significant acute toxicity.