起源于支气管 K 细胞(Kulchitzky Cell)的癌即称为支气管 K 细胞癌(KulchitzkyCell Carcinoma,KCC),它包括 KCC Ⅰ(典型的支气管类癌)、KCCⅡ(不典型支气管类癌)、KCCⅢ(小细胞性肺癌,亦称 SCCL)。鉴于它们共同的起源和具有产生内分泌激素的功能,又因各自不同的生物学特性而反映了临床表现、治疗和预后等方面的显著差异,为此,KCC 近年来颇受人们的注目。一、组织学起源KCC 的起源是支气管粘膜的 K 细胞。在人体气道粘膜上皮的基底部(或粘液腺内),散 Carcinomas originating from bronchial K cells are called Klchitzky Cell Carcinoma (KCC) and include KCC I (typical bronchiolocarcinoma), KCCII (atypical bronchial carcinoid), and KCCIII (small cell). Lung cancer, also known as SCCL). In view of their common origin and function of producing endocrine hormones, and because of their different biological characteristics, they reflect significant differences in clinical manifestations, treatment, and prognosis. For this reason, KCC has attracted much attention in recent years. 1. Histological Origins The origin of KCC is the K cells of the bronchial mucosa. In the base of the human airway mucosal epithelium (or within the mucous glands), scattered