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在30只麻醉兔上观察了心得宁和妥拉苏林抗枸椽酸钠所致的室颤的作用。使用β-肾上腺素能阻断剂心得宁可使动物枸椽酸钠的累积致死量增高,室颤出现时间推迟或完全不出现。使用α-阻断剂妥拉苏林时,这种对抗致颤效应更为明显,能完全取消枸椽酸钠降低室颇阈的作用。同时使用心得宁和妥拉苏林可使枸椽酸钠的累积致死量大为增高,大部分兔死于心搏无力而非室颤。结果提示,β-受体阻断剂只能部分地对抗心脏交感-肾上腺素能活动反射性所诱发的室颤。单独使用。α-阻断剂或与、β-阻断剂结合使用才能较有效地对抗致颤作用。这些结果指出,α-肾上腺素能受体阻断剂在治疗心律失常中是有价值的。关于α-肾上腺素能受体在室颤中的可能机制,文中作了讨论。
The effect of dextromethorphan and torethulin on the ventricular fibrillation induced by sodium citrate was observed in 30 anesthetized rabbits. Adoption of beta-adrenergic blockers would rather increase the cumulative lethal dose of sodium citrate in animals, and the onset of ventricular fibrillation may be delayed or completely absent. The use of α-blocker torethulin, the antagonistic effect of defibrillation more obvious, can completely cancel the role of sodium citrate to reduce the threshold quite room. At the same time using the experience Ning and Torazulin can cause a large increase in the cumulative lethal sodium citrate, most of the rabbits died of heart failure rather than ventricular fibrillation. The results suggest that beta-blockers can only partially counteract ventricular fibrillation induced by cardiac sympathetic-adrenergic reflex activity. Use alone. Alpha-blockers or in combination with beta-blockers can be more effective in counteractive defibrillation. These results indicate that alpha-adrenergic receptor blockers are valuable in the treatment of cardiac arrhythmias. The possible mechanism of α-adrenergic receptors in ventricular fibrillation is discussed in this article.