不同种类动物,包括啮齿动物,常被用来改进肿瘤放射治疗的研究。但就临床实践而言,一些动物模型是否适用,却尚未得到明确证明。由动物外推到人的正确性也还有待检验。按每份额高能中子剂量函数的皮肤损伤来测定其对活体的r.b.e.的实验表明,象人、小鼠、猪和大鼠等不同种类动物的反应是相等的。采用另一个方法,即观察成纤维细胞群体培养物生命期,作者业已证明细胞对电离辐射的反应依赖于细胞的种属。对小鼠成纤维细胞,其永久细胞株的建 Different species of animals, including rodents, are often used to improve the study of tumor radiotherapy. However, in clinical practice, the applicability of some animal models has not yet been clearly demonstrated. The correctness of extrapolating from animals to humans has yet to be tested. Experiments on r.b.e. in vivo determined as skin damage per serving of high energy neutron dose function showed that the responses of different species such as humans, mice, pigs, and rats were equal. Using another approach, which is to look at the life span of a fibroblast population culture, the authors have demonstrated that the response of cells to ionizing radiation depends on the cell species. On mouse fibroblasts, their permanent cell lines were built