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何首乌为蓼科植物何首乌的块根。味甘、苦、涩、性微温。具有“补肝益肾,强筋益髓,养血黑发,延年不老”之功效,,祖国医学抗衰老药物。近年来人们对何首乌的抗衰老作用进行了不少的研究,为此,本文就近十年来有关何首乌的抗衰药理与临床应用综述如下。 1 药理作用 1.1 对寿命的影响 郑志学等人在实验中发现何首乌组能使二倍体细胞有延长传代周期作用,比对照组延长3～4天左右。在反相显微镜和扫描镜下证实它能使2倍体细胞外形、细胞表面结构和细胞器维持较好的形态。戴光仁等发现饲喂制首乌提取液,对雄、雌果蝇的半数死亡时间均有明显的延长作用,并且还显示一定的性别差异。在雄性中,制首乌的作用最为明显,半数死亡时间平均为57.5天,比对照组(42天)长15.5天。
Polygonum multiflorum is the root of the plant Polygonum multiflorum. Sweet, bitter, astringent, tepid. With the “Bugan Yishen, strong gluten marrow, nourishing black hair, aging is not old” effect, the motherland medicine anti-aging drugs. In recent years, people have done a lot of research on the anti-aging effects of Polygonum multiflorum. To this end, this article summarizes the anti-aging pharmacology and clinical application of Polygonum multiflorum for the past decade. 1 pharmacological effects 1.1 on the longevity of Zheng Zhixue and others in the experiment found that Polygonum multiflorum can make the cells have a prolonged passaging cycle, than the control group extended 3 to 4 days. It was confirmed by inverted microscope and scanning microscope that it can maintain a better morphology of the diploid cell shape, cell surface structure and organelles. Dai Guangren et al. found that the feeding of Radix Polygoni multiflori extract had significant prolongation of half of the death time of male and female fruit flies, and also showed certain gender differences. Among males, the system of Shouwu is most effective, with an average of 57.5 days of death, which is 15.5 days longer than the control group (42 days).