目的制备符合质量要求的枸橼酸莫沙必利咀嚼片。方法采用湿法制粒工艺制备枸橼酸莫沙必利咀嚼片。选用正交试验优选处方,对优化处方进行溶出、口感检查。结果优选处方制备的枸橼酸莫沙必利咀嚼片质量合格。结论可溶性辅料利于药物的溶出,随粘合剂量的增加可延缓药物的溶出。 Objective To prepare mosapride citrate chewable tablets which meet the quality requirements. Methods The wet granulation process was used to prepare mosapride citrate chewable tablets. Orthogonal test using the preferred prescription, the optimal prescription for dissolution, texture inspection. Results The prescription of mosapride citrate chewable tablets was qualified. Conclusion The soluble adjuvant is good for the dissolution of the drug. With the increase of the adhesive dose, the dissolution of the drug can be delayed.