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目的评价血清中Ⅳ型胶原(CⅣ)含量变化与纤维化程度病理分期的相关性。方法采用肝穿刺活检对97例慢性乙肝患者进行肝组织纤维化分期(S),并利用化学发光法定量测定试剂盒对患者的血清进行Ⅳ型胶原(CⅣ)指标检测,结合两种方法分析血清学指标在肝纤维化诊断中的价值。结果 CⅣ与肝组织纤维化程度相关(r=0.529,P<0.01),随着肝纤维化程度的加重,患者血清CⅣ含量呈上升趋势。结论 CⅣ指标对判断肝纤维化程度有一定指导意义,为开展肝纤维化的无创诊断打下基础。
Objective To evaluate the correlation between the serum level of type Ⅳ collagen (Ⅳ) and the pathological stage of fibrosis. Methods Liver biopsy was performed in 97 patients with chronic hepatitis B by liver biopsy. The chemoserum luminescence method was used to detect the level of collagen Ⅳ (C Ⅳ) in the serum of patients. Serum was analyzed by two methods The value of learning indicators in the diagnosis of liver fibrosis. Results CⅣ was correlated with the degree of liver fibrosis (r = 0.529, P <0.01). With the severity of liver fibrosis, serum CⅣ level increased. Conclusion C Ⅳ index has certain guiding significance for judging the degree of liver fibrosis, laying a foundation for the noninvasive diagnosis of liver fibrosis.