凋亡是一种主动方式的程序性细胞死亡 ,它的形态特征为细胞固缩、核碎裂。近来 Majno提出一种表现为细胞肿胀和核溶解的细胞损伤过程 ,称之为胀亡 (oncosis)。目前 ,毒理病理学家认为凋亡和胀亡代表了两种不同的细胞死亡方式。本文对细胞胀亡的病理形态特征、生化改变和发生机制、分子调控的初步研究进展及其与凋亡的联系进行综述 ,以利于加深对细胞死亡方式的进一步认识 Apoptosis is an active way of programmed cell death, its morphological characteristics of cell shrinkage, nuclear fragmentation. Majno recently proposed a cell injury process that manifests itself as swelling and lysis of cells called oncosis. At present, toxicological pathologists believe that apoptosis and bulging represent two different ways of cell death. In this paper, the pathological features, biochemical changes and mechanisms of cell death, the preliminary research progress of molecular regulation and their relationship with apoptosis were reviewed in order to further deepen the understanding of cell death patterns