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This study sought to investigate whether low dose dobutamine MRI can detect residual myocardial viability in patients with chronic myocardial infarction and left ventricular dysfunction. Methods. Eleven patients with chronic myocardial infarction and left ventricular dysfunction were employed for identification of viable myocardium by cine MRI during dobutamine infusion. All patients underwent coronary angiography and left ventriculography, 18 FDG PET, MRI at rest and stress.The systolic wall thickening measured at rest and during stress was compared with the results of 18 FDG PET, respectively. Results. A significant difference of either dobutamine induced systolic wall thickening (SWth stress ) or dobutamine induced contractile reserve (ΔSWth= SWth stress - SWth rest ) was present between viable and scar regions (1 0±0 3 versus -0 3 ±0 1, P<0 01; 1 0±0 3 versus -0 2±0 2, P<0 01). Conclusions. Dobutamine induced contractile reserve can be predicted in the regions of akinesia or dyskinesia at rest when systolic wall thickening was 1 0 mm during dobutamine stimulation.
Methods study to investigate whether low dose dobutamine MRI can detect residual myocardial viability in patients with chronic myocardial infarction and left ventricular dysfunction. Methods. Eleven patients with chronic myocardial infarction and left ventricular dysfunction were employed for identification of viable myocardium by cine MRI during dobutamine All patients underwent coronary angiography and left ventriculography, 18 FDG PET, MRI at rest and stress. Stress systolic wall thickening at rest and during stress was compared with the results of 18 FDG PET, respectively. A significant difference of either dobutamine induced systolic wall thickening (SWth stress) or dobutamine induced contractile reserve (ΔSWth = SWth stress - SWth rest) was present between viable and scar regions (1 0 ± 0 3 versus -0 3 Dobutamine-induced contractile reserve can be predicted in the regions of akinesia or dyskinesia at rest when systolic wall thickening (P <0.01; P <0.01; P <0.01 vs P <0.01) was 1 0 mm during dobutamine stimulation.