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目的探讨糖化白蛋白(GA)、糖化血红蛋白(HbA_(1c))、空腹血糖(FPG)和餐后2 h血糖(OGTT-2hPG)联合检测在肇庆市城区2型糖尿病患者诊断中的应用评价分析,为公共卫生部门制定2型糖尿病的预防和控制规划提供科学依据。方法收集2016年12月-2017年2月肇庆某医院体检健康者及内科住院患者共374例,检测相应的GA、HbA_(1c)、FPG和OGTT-2hPG等参数。结果肇庆市城区正常糖调节人群的GA参考值为10.66%~15.56%,GA水平呈正态分布。与正常糖调节组相比,GA、HbA_(1c)、FPG和OGTT-2h PG在血糖受损组及2型糖尿病患者组均有明显升高,差异有统计学意义(P<0.05)。在2型糖尿病患者组中,GA、HbA_(1c)分别与FPG、OGTT-2hPG呈正相关。结论 GA、HbA_(1c)、FPG和OGTT-2hPG联合检测在肇庆市城区2型糖尿病患者诊断中具有较高的临床应用价值,值得推广应用。
Objective To investigate the application of combined detection of glycosylated albumin (GA), glycosylated hemoglobin (HbA 1c), fasting plasma glucose (FPG) and postprandial 2h blood glucose (OGTT-2hPG) in the diagnosis of type 2 diabetes mellitus , Providing the scientific basis for the public health department to formulate the prevention and control plan of type 2 diabetes. Methods A total of 374 healthy volunteers and medical inpatients from a hospital in Zhaoqing from December 2016 to February 2017 were enrolled in this study. The corresponding GA, HbA_ (1c), FPG and OGTT-2hPG parameters were detected. Results GA reference value of normal sugar-regulated population in Zhaoqing city was 10.66% -15.56%, GA level was normal distribution. The levels of GA, HbA_ (1c), FPG and OGTT-2h PG were significantly higher in patients with impaired glucose tolerance and type 2 diabetes than those in normal glucose control group (P <0.05). In type 2 diabetic patients, GA and HbA 1c were positively correlated with FPG and OGTT-2hPG, respectively. Conclusion The combination of GA, HbA_ (1c), FPG and OGTT-2hPG has a high clinical value in the diagnosis of type 2 diabetes mellitus in urban areas of Zhaoqing City, which is worth popularizing and applying.