论文部分内容阅读
目的探讨中枢神经系统T细胞增殖症的临床表现、影像特点和病理特征以及治疗策略。方法对病理活检诊断明确的3例中枢神经系统T细胞增殖症病例进行临床资料分析。结果中枢神经系统T细胞增殖症主要临床表现为急性或亚急性起病,偏瘫、共济失调等神经系统功能缺损,但缺乏特异性表型。头颅影像学表现以脑白质病变以及脑干、小脑累及的占位性病变为主,伴有明显团块样、点状或环形强化。病理活检提示病灶中大量T细胞浸润。经过免疫抑制治疗患者预后良好。结论中枢神经系统T细胞增殖症是一种罕见的疾病,经病理活检可确诊,积极治疗预后较好,但需临床医生重视。
Objective To investigate the clinical manifestations, imaging features, pathological features and therapeutic strategies of central nervous system T cell proliferative disorder. Methods The clinical data of 3 cases of central nervous system T cell proliferative disease diagnosed by biopsy were analyzed. Results The main clinical manifestations of central nervous system T cell proliferation were acute or subacute onset, hemiplegia, ataxia and other neurological deficits, but the lack of specific phenotype. Head imaging manifestations of leukoencephalopathy and brain stem, cerebellar involvement of the dominant lesions, with obvious mass-like, punctate or ring-shaped enhancement. Pathological biopsy prompted a large number of T-cell infiltration in the lesion. After immunosuppressive treatment of patients with good prognosis. Conclusion CNS T cell proliferation is a rare disease which can be diagnosed by pathological biopsy. The prognosis of active treatment is good, but it needs clinicians’ attention.