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目的探讨癫痫患儿应用卡马西平(CBZ)和丙戊酸钠(VPA)对脑电图的影响。方法对31例单独应用CBZ和35例单独应用VPA,临床发作缓解的两组病例进行脑电图(EEG)分析。结果CBZ组48.4%病人痫样放电减少或消失。22.6%痫样放电反而增加。VPA组80%病人痫样放电明显减少或消失。结论CBZ和VPA可使临床发作控制,但CBZ组却有22.6%的病人痫样放电增加,同时引起EEG背景活动慢化,表现为α活动减少,θ波增加,δ波增加,因此脑电图不能作为卡马西平治疗有效的一种指标。
Objective To investigate the effects of carbamazepine (CBZ) and valproate (VPA) on the electroencephalogram in children with epilepsy. Methods Electroencephalography (EEG) analysis was performed in 31 cases of CBZ alone and in 35 cases of VPA alone and with clinical remission. Results 48.4% of patients in CBZ group had reduced or disappeared epileptiform discharges. 22.6% epileptiform discharge instead increased. 80% of VPA patients with epileptiform discharge significantly reduced or disappeared. Conclusions CBZ and VPA can control clinical seizure. However, in CBZ group, 22.6% of patients showed an increase of epileptiform discharge and caused a decrease of EEG background activity. The results showed that α activity decreased, θ increased, and δ increased. Therefore, EEG Not as an effective indicator of carbamazepine treatment.