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目的:探讨脉搏波传导速度(PWV)检测在评估高血压病患者大动脉弹性中的应用价值与影响因素分析。方法:采用分层整体抽样法随机抽取高血压病患者2178例,同时抽取非高血压2182人作为对照组。应用Complior SP VP-1000动脉硬化检测仪测定颈-股动脉脉搏波传导速度(C-FPWV)评估大动脉弹性。采用多元逐步线性回归分析性别、年龄、体质指数(BMI)、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、甘油三脂(TG)、空腹血糖(FPG)和尿酸(UA)等指标与高血压病患者大动脉弹性下降的影响因素。结果:C-FPWV平均值高血压组(1594±264cm/s)显著高于对照组(1216±231cm/s),两组差异有显著性意义(X2=31.659,P=0.00)。>40岁各年龄段PWV值上升程度,高血压组明显高于对照组(X2=18.954～36.924,P=0.00),两组PWV值上升程度与年龄呈正相关。多元逐步线性回归分析表明:BMI≥28kg/m2、SBP≥140mmHg、DBP≥90mmHg、TC>5.28±0.62 mmol/L、TG>1.68±0.64mmol/L等指标高血压组明显高于对照组(t=14.314～17.428,P<0.05)。在性别、UA和FPG等指标两组无明显差异(X2=6.368～13.618,P>0.05)。结论:高血压病患者PWV值上升程度显著高于非高血压者,BMI、SBP、TG、TC是高血压病患者大动脉弹性下降的主要影响因素。PWV值可作为评价大动脉弹性的可靠指标。
Objective: To investigate the value and influential factors of pulse wave velocity (PWV) detection in estimating arterial elasticity in hypertensive patients. Methods: Totally 2178 cases of hypertension were randomly selected by stratified sampling method, and 2182 non-hypertension patients were taken as the control group. The aorta elasticity was evaluated using the Complior SP VP-1000 Arteriosclerosis Detector to measure the cervical-femoral artery pulse wave velocity (C-FPWV). Multivariate stepwise linear regression analysis was used to analyze gender, age, body mass index (BMI), SBP, DBP, TC, TG, FPG and UA ) And other indicators of hypertensive patients with arterial elasticity decreased factors. Results: The C-FPWV mean hypertension group (1594 ± 264 cm / s) was significantly higher than that of the control group (1216 ± 231 cm / s). There was significant difference between the two groups (X2 = 31.659, P = 0.00). > PWV value in all age groups> 40 years old, hypertension group was significantly higher than that in control group (X2 = 18.954 ~ 36.924, P = 0.00). There was a positive correlation between PWV and age. Multivariate stepwise linear regression analysis showed that the indexes of hypertension such as BMI≥28kg / m2, SBP≥140mmHg, DBP≥90mmHg, TC> 5.28 ± 0.62mmol / L and TG> 1.68 ± 0.64mmol / L were significantly higher than those of the control group = 14.314 ~ 17.428, P <0.05). There was no significant difference in gender, UA and FPG between the two groups (X2 = 6.368 ~ 13.618, P> 0.05). Conclusions: The PWV of hypertension patients is significantly higher than that of non-hypertension patients. BMI, SBP, TG and TC are the main influencing factors of arterial elasticity decline in hypertensive patients. PWV value can be used as a reliable indicator of aortic elasticity.