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为探讨尼可地尔静脉滴注（静滴）对急性心肌梗塞（AMI）犬冠状动脉侧支循环和梗塞范围的影响，在12只麻醉开胸犬上结扎冠状动脉左前降支，远端插管建立侧支返流模型。实验组在缺血5min后静滴尼可地尔200μg／kg；对照组静滴等容积生理盐水。在不同时项上观察心脏血流动力学和侧支循环指标，缺血120min后以称重法测定心肌梗塞（MI）面积。结果：与缺血5min的基础值相比，实验组外周冠状动脉压显著下降，冠状动脉侧支流量显著增加，侧支系统阻力及外周冠状动脉阻力显著下降，而对照组无明显变化。实验组MI范围较对照组显著下降。表明：尼可地尔能改善AMI犬的冠状动脉侧支循环，并能限制MI范围。
To investigate the effect of nicorandil intravenous drip (IV infusion) on coronary collateral circulation and infarct size in acute myocardial infarction (AMI) dogs, left anterior descending coronary artery was ligated in 12 anesthetized thoracotomy dogs. Distal insertion Tube to establish collateral flow model. In the experimental group, Nicorandil 200 μg / kg was injected intravenously 5 min after ischemia, and the control group was given the same volume of normal saline. Cardiac hemodynamics and collateral circulation indices were observed at different time points. The area of myocardial infarction (MI) was determined by weighing method 120 min after ischemia. Results: Compared with the baseline value of ischemia 5 min, the peripheral coronary pressure decreased significantly, the collateral flow increased significantly, the resistance of collateral system and the resistance of peripheral coronary artery decreased significantly, but there was no significant change in the control group. MI range of experimental group than the control group decreased significantly. Nicorandil improved AMI canine coronary collateral circulation, and can limit the MI range.