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目的：观察多塞平对大鼠急性脑缺血再灌注引起损伤的保护作用。方法：６０只大鼠，分为多塞平大、中、小剂量（１５，１０，５ｍｇ／ｋｇ）组，尼莫地平阳性对照组、空白对照组和假手术对照组。用阻断四血管方法造成大鼠急性脑缺血再灌注损伤，原子吸收分光光度计测定脑组织Ｃａ２＋，Ｎａ＋，Ｋ＋的含量。结果：与空白对照组比较，尼莫地平阳性对照组和多塞平大、中剂量组脑组织Ｃａ２＋，Ｎａ＋，Ｈ２Ｏ含量显著降低（Ｐ＜０．０５或Ｐ＜０．０１）；多塞平小剂量组脑组织Ｃａ２＋含量显著降低（Ｐ＜０．０５），其余含量变化均不显著（Ｐ＞０．０５）。结论：多塞平能显著降低因缺血引起的脑组织Ｃａ２＋，Ｎａ＋，Ｈ２Ｏ含量增高，表现出钙拮抗作用
Objective: To observe the protective effect of doxepin on acute cerebral ischemia-reperfusion-induced injury in rats. Methods: Sixty rats were divided into two groups: large, medium and small doses of doxepin (15, 10, and 5 mg / kg), nimodipine positive control group, blank control group and sham operation control group. Acute cerebral ischemia-reperfusion injury was induced by blocking the four-vessel method. The content of Ca2 +, Na +, K + in brain tissue was measured by atomic absorption spectrophotometer. Results: Compared with the blank control group, the levels of Ca2 +, Na +, H2O in the nimodipine positive control group and the doxepin large and medium dose groups were significantly decreased (P <0.05 or P <0.01) The content of Ca2 + in brain tissue of low dose group was significantly decreased (P <0.05), but the content of other contents did not change significantly (P> 0.05). CONCLUSION: Doxepin can significantly reduce the content of Ca2 +, Na +, H2O in brain tissue induced by ischemia, showing calcium antagonism