目的观察镉对巨噬细胞功能的影响。方法以０．３、０．６、１．２ｍｇ／ｋｇ体重ＣｄＣｌ２连续给小鼠灌胃１４天后进行巨噬细胞吞噬功能、产生ＮＯ的能力及产生Ｈ２Ｏ２等多个指标的检测。结果在各剂量ＣｄＣｌ２作用下，小鼠腹腔灌洗液细胞数减少，与对照组比差异有显著性。巨噬细胞吞噬功能受到明显抑制，抑制率分别为２１．８％、３９．９％、４４．４％，且呈现剂量反应关系（ｒ＝－０．９０３１）。巨噬细胞产生ＮＯ的能力也受到明显抑制，对照组为７６．１０±１４．２２μｍｏｌ／Ｌ，其于各组分别为６１．９０±２７．８３、３６６７±２３．８６、４６．６０±１３．３３μｍｏｌ／Ｌ。巨噬细胞产生的Ｏ－２在三种剂量下都出现明显抑制，呈现剂量反应关系（ｒ＝０．９７９０）。巨噬细胞产生Ｈ２Ｏ２的能力仅在１．２ｍｇ／ｋｇ剂量时出现明显抑制，与对照组比差异有显著性，但Ｈ２Ｏ２的产生与ＣｄＣｌ２剂量亦存在剂量反应关系（ｒ＝－０．９８４７）。结论ＣｄＣｌ２在０３、０．６、１．２ｍｇ／ｋｇ剂量下对巨噬细胞吞噬功能，ＮＯ、Ｏ－２、Ｈ２Ｏ２等生物分子的产生均有明显抑制。因此认为ＣｄＣｌ２可直接影响巨噬细胞的抗原递呈及非特异性防御功能 Objective To observe the effect of cadmium on the function of macrophages. Methods The mice were gavaged with 0.3, 0.6, 1.2 mg / kg body weight of CdCl2 for 14 days. The phagocytosis of macrophages, the ability to produce NO and the production of H2O2 were detected. Results Under the action of various doses of CdCl2, the number of peritoneal lavage fluid cells in mice decreased, which was significantly different from the control group. Phagocytic function of macrophages was significantly inhibited, the inhibition rates were 21.8%, 39.9%, 44.4%, and the dose-response relationship (r = -0.9031). The ability of macrophages to produce NO was also significantly inhibited, the control group was 76.10 ± 14.22μmol / L, which in each group were 61.90 ± 27.83,3667 ± 23.86,46.60 ± 13.33 μmol / L. O-2 produced by macrophages was significantly inhibited in all three doses, showing a dose-response relationship (r = 0.9790). The ability of macrophages to produce H2O2 was significantly inhibited only at a dose of 1.2 mg / kg, which was significantly different from that of the control group. However, there was dose-response relationship between the generation of H2O2 and the dose of CdCl2 (r = -0.9847) . Conclusions CdCl2 inhibited the phagocytosis of macrophages and the production of NO, O-2 and H2O2 at the dosages of 0.3, 0.6 and 1.2 mg / kg respectively. So that CdCl2 can directly affect macrophages antigen presentation and nonspecific defensive function