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为观察链球菌组蛋白样蛋白 (HlpA)对小鼠血清白细胞介素 6 (IL 6 )质量浓度的影响 ,经小鼠尾静脉注射HlpA ,用 7TD1IL 6依赖株的细胞存活率测定小鼠血清IL 6质量浓度。发现 :链球菌HlpA( 0～ 30 0 μg/只 )以剂量和时间依赖方式促进小鼠血清IL 6升高 (P <0 .0 5～P <0 .0 1)。脂磷壁酸 (LTA)和HlpA有协同增强作用 ;抗HlpA和肝素则对HlpA起抑制作用。提示 :纯化的链球菌HlpA刺激小鼠血细胞过量产生IL 6 ,LTA对此有增强作用 ,抗HlpA和肝素则有抑制作用
In order to observe the effect of HlpA on the concentration of serum IL-6 in mice, HlpA was injected into the tail vein of mice and the serum IL-6 level of mice was determined by cell viability of 7TD1IL6- 6 mass concentration. It was found that Streptococcus HlpA (0 ~ 30 0 μg / body) promoted the increase of serum IL 6 in a dose-and time-dependent manner (P <0.05 ~ P <0.01). Lipoteichoic acid (LTA) and HlpA have a synergistic effect; anti-HlpA and heparin inhibit HlpA. Hint: Purified Streptococcus HlpA stimulates excessive production of IL-6 in mouse blood cells, which is enhanced by LTA and inhibited by HlpA and heparin