论文部分内容阅读
硝酸和四氧化氮广泛用于化学工业和国民经济其他部门,具有很大的吸入毒性,对粘膜和肺组织导致腐蚀作用,并可伴随产生变性血红蛋白血症。本文报导硝酸和四氧化氮损害皮肤引起的毒性。实验用104只体重180～200 g大鼠,使皮肤深度损害面积在Ⅰ组中为30 cm~3和60 cm~3,在Ⅱ组为25%体表面积。皮肤损害面积按公式计算。以吸管吸取硝酸或四氧化氮(1 ml/cm~3),均匀滴于皮肤脱毛部位,使皮肤受深度损害。为了排除大鼠吸入硝酸和四氧化氮蒸气,受到吸人损害,实验在通风橱中进行,以特制套子,戴在鼠头上以保护呼吸器管。在损伤后1小时测定硝基化合物吸收量和变性血红蛋白量。开胸从心脏取血。硝酸盐测定按法,变性血红蛋白测定用-10分光光度计。
Nitric acid and nitrogen tetraoxide are widely used in chemical industry and other sectors of the national economy, have a great inhalation toxicity, cause corrosive effects on mucosa and lung tissue, and may be accompanied by degeneration of hemoglobinemia. This article reports that nitric acid and nitric oxide impair skin-induced toxicity. In the experiment, 104 rats with a body weight of 180-200 g were used, and the depth of skin damage area was 30 cm 3 and 60 cm 3 in Group I and 25% body surface area in Group II. Skin damage area according to the formula. Pipette to absorb nitric acid or nitrogen oxide (1 ml / cm ~ 3), evenly drops on the skin depilatory area, the skin affected by the depth of damage. In order to exclude rat inhalation of nitric acid and nitrogen oxide vapor, inhalation damage, the experiment carried out in a fume hood to a special cover, worn on the head to protect the respirator tube. The amount of nitro compound uptake and denatured hemoglobin were determined 1 hour after injury. Chest threw blood from the heart. Determination of nitrate According to the law, denatured hemoglobin determination with -10 spectrophotometer.