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脑缺血是威胁人类健康的主要疾病之一,具有高发病率;高致残率和高死亡率等特点。脑缺血或缺血性脑中风是指脑内血液供应障碍导致的大脑某区域的缺血、缺氧。脑的血流量为750~1000 ml/min,耗氧量约占人体总耗氧量的20%,所以脑组织对缺血缺氧非常敏感。众所周知,脑缺血会引发一系列的有害反应,从而导致缺血脑组织细胞内稳态的破坏和结构的损伤,最终导致缺血后急性坏死、程序性坏死、细胞凋亡和自噬等,还包括氨基酸兴奋性毒、细胞内钙离子超载、氧
Cerebral ischemia is one of the major diseases that threaten human health, with high morbidity, high morbidity and mortality. Cerebral ischemia or ischemic stroke refers to the brain ischemia and hypoxia in some area of the brain caused by blood supply disorders. Brain blood flow of 750 ~ 1000 ml / min, oxygen consumption accounts for about 20% of total human oxygen consumption, so brain tissue is very sensitive to ischemia and hypoxia. Is well known that cerebral ischemia can trigger a series of harmful reactions, leading to ischemia-induced destruction of intracellular homeostasis and structural damage, and ultimately lead to acute necrosis after ischemia, programmed necrosis, apoptosis and autophagy, Also includes amino acid excitotoxicity, intracellular calcium overload, oxygen