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目的:观察前列腺素E_1治疗慢性重症肝炎的疗效。方法:采用前列腺素E_1治疗慢性重症肝炎,与同期应用常规方法治疗的病例对照比较,重点观察对慢性重症肝炎病人血清胆红素(SB)和凝血酶元活动度(PTA)及对存活率的影响。结果:治疗组SB下降及PTA升高平均值分别为167±12μmol/L,34％±3.6％,生存率为48％;对照组SB下降及PTA升高平均值分别为87.5±3.7μmol/L,11％±1.8％,生存率为10％,3项P均<0.01。结论:前列腺素E_1治疗慢性重症肝炎有确切疗效。
Objective: To observe the efficacy of prostaglandin E_1 in the treatment of chronic severe hepatitis. Methods: The prostaglandin E_1 was used in the treatment of chronic severe hepatitis. Compared with the case-control cases treated by routine method in the same period, we focused on the observation of serum bilirubin (SB), thrombin meta-activity (PTA) and survival rate in patients with chronic severe hepatitis influences. Results: The SB and PTA in treatment group were 167 ± 12μmol / L, 34% ± 3.6% and 48%, respectively. The mean SB and PTA in control group were 87.5 ± 3.7μmol / L , 11% ± 1.8%, the survival rate was 10%, 3 P <0.01. Conclusion: Prostaglandin E_1 has the exact effect in treating chronic severe hepatitis.