肾上腺髓质素对大鼠肺缺血再灌注损伤的保护作用

来源 :中华实验外科杂志 | 被引量 : 0次 | 上传用户：wlm7411814

【摘要】

：

目的观察肾上腺髓质素(ADM)在肺缺血再灌注损伤的保护作用.方法三套管法建立大鼠左肺移植模型,分对照组和静脉ADM给药组(每分钟0.05μ/kg体重),分别进行髓过氧化物酶(MPO)

【作者】

：

陈乾坤姜格宁丁嘉安

【机构】

：

同济大学附属上海肺科医院胸外科

【出处】

：

中华实验外科杂志

【发表日期】

：

2004年期

【关键词】

：

肾上腺髓质素肺缺血再灌注损伤 Adrenomedullin Lung lschemia Reperfusion injury

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目的观察肾上腺髓质素(ADM)在肺缺血再灌注损伤的保护作用.方法三套管法建立大鼠左肺移植模型,分对照组和静脉ADM给药组(每分钟0.05μ/kg体重),分别进行髓过氧化物酶(MPO)活性测定、移植肺支气管肺泡灌洗液(BAL)中性粒细胞计数、缺血再灌注后血气分析以及移植肺组织湿/干(W/D)重最比测定.结果再灌注4 h后,对照组的MPO活性(0.45±0.07)显著大于ADM给药组(0.24±0.06),差异有统计学意义(t=2.764,P

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肾上腺髓质素对大鼠肺缺血再灌注损伤的保护作用

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