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肝胆恶性肿瘤病人只有极少数能手术治疗,不能手术者预后极差。近年随同位素输送方法和治疗比率的改善,不能手术者同位素治疗也随之增加。~(192)Ir丝与内假体联合应用治疗恶性胆管狭窄的疗效可与旁路手术媲美;~(131)Ⅰ标记碘油可应用潜在的肿瘤破坏剂量而无明显毒性反应;~(90)Yt是目前治疗效能最大的同位素,但因致死性副作用使其应用受限。欲发掘肝胆恶性肿瘤同位素治疗的最大潜力,应从放射治疗技术和肿瘤生物学两方面进行更深入细致的研究。
Only a small number of patients with hepatobiliary malignancies can be treated with surgery. Those who cannot undergo surgery have a very poor prognosis. With the improvement of isotope delivery methods and treatment rates in recent years, inoperable isotope therapy has also increased. The efficacy of ~(192)Ir silk combined with endoprostheses in the treatment of malignant biliary stenosis is comparable to that of bypass surgery; ~(131)I-labeled lipiodol can be used as a potential tumor destruction dose without significant toxicity; ~(90) Yt is currently the most effective isotope, but its use is limited due to lethal side effects. To discover the greatest potential of isotope therapy for malignant tumors of the liver and gallbladder, more in-depth studies should be conducted on both radiotherapy and tumor biology.