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目的:探讨保儿宁联合孟鲁司特治疗儿童变应性鼻炎的临床效果。方法:选择2015年7月—2016年7月医院诊治的90例变应性鼻炎患儿为研究对象,根据随机数字表法将其分为观察组和对照组,各45例。对照组采用布地奈德吸入+孟鲁司特钠口服。观察组在其基础上应用保儿宁颗粒口服,疗程均为3个月。比较两种患者疗效、治疗前后免疫指标及炎性因子的差异。结果:治疗后,观察组患儿治疗总有效率(93.3%)显著高于对照组患儿(75.6%),差异具有统计学意义(P<0.05),治疗后,观察组患儿鼻炎症状评分及哮喘症状评分均显著低于对照组[(4.2±1.2)vs(5.3±1.3)分;(4.1±0.8)vs(4.7±1.2)分],呼吸道感染次数明显低于对照组患儿[(0.5±0.1)vs(0.7±0.4)次],差异具有统计学意义(P<0.05)。治疗后,两组患儿CD_3~+、CD_4~+、CD_4~+/CD_8~+水平均明显升高,CD_8~+水平明显降低,差异具有统计学意义(P<0.05)。组间比较,观察组患儿治疗后CD_3~+(66.38%±10.19%)、CD_4~+(39.65%±7.37%)及CD_4~+/CD_8~+(1.96±0.55)水平均明显高于对照组患儿,CD_8~+(25.67%±3.47%)水平均明显低于对照组患儿,差异具有统计学意义(P<0.05)。治疗后,观察组患儿治疗后IL-4明显低于对照组患儿[(8.14±1.85)vs(22.45±3.77)μg·L-1],IFN-γ水平显著高于对照组患儿[(206.44±22.58)vs(159.78±17.33)μg·L-1],差异具有统计学意义(P<0.05)。结论:保儿宁联合孟鲁司特治疗儿童变应性鼻炎具有良好的效果,在改善临床症状的同时可以明显改善患儿免疫指标及炎性因子水平。
Objective: To investigate the clinical effect of Paulingling combined with montelukast on children allergic rhinitis. Methods: Ninety children with allergic rhinitis diagnosed from July 2015 to July 2016 in our hospital were selected as study subjects, and divided into observation group and control group according to random number table method, with 45 cases in each group. Control group budesonide inhalation + montelukast sodium orally. Observation group based on the application of Bao’ering granules oral treatment for 3 months. Compare the curative effect of two kinds of patients, the immune index before and after treatment and the difference of inflammatory factor. Results: After treatment, the total effective rate (93.3%) in the observation group was significantly higher than that in the control group (75.6%), the difference was statistically significant (P <0.05). After treatment, the rhinitis symptom score (4.2 ± 1.2) vs (5.3 ± 1.3) points; (4.1 ± 0.8) vs (4.7 ± 1.2) points respectively, and the number of respiratory infections was significantly lower than that in the control group [( 0.5 ± 0.1 vs 0.7 ± 0.4), the difference was statistically significant (P <0.05). After treatment, the levels of CD_3 ~ +, CD_4 ~ + and CD_4 ~ + / CD_8 ~ + in both groups were significantly increased and the levels of CD_8 ~ + were significantly decreased in both groups (P <0.05). The levels of CD_3 ~ + (66.38% ± 10.19%), CD_4 ~ + (39.65% ± 7.37%) and CD_4 ~ + / CD_8 ~ + (1.96 ± 0.55) in the observation group were significantly higher than those in the control group The levels of CD_8 ~ + (25.67% ± 3.47%) were significantly lower than those of the control group, the difference was statistically significant (P <0.05). After treatment, the level of IL-4 in the observation group was significantly lower than that in the control group [(8.14 ± 1.85) vs (22.45 ± 3.77) μg · L -1], and the level of IFN-γ in the observation group was significantly higher than that in the control group [ (206.44 ± 22.58) vs (159.78 ± 17.33) μg · L-1, respectively), the difference was statistically significant (P <0.05). Conclusion: Bao-na-ning combined with montelukast in children with allergic rhinitis has a good effect, while improving clinical symptoms can significantly improve children with immune indicators and inflammatory cytokines levels.