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目的探讨胰腺导管内嗜酸性乳头状肿瘤的临床和病理组织学特征、可能的病因、诊断及鉴别诊断。方法对1例胰腺导管内嗜酸性乳头状肿瘤的临床、组织病理学以及免疫组化结果进行分析,并文献复习。结果肿瘤发生无性别差异,临床症状可表现为上腹部不适或疼痛。肿瘤主要发生于胰腺大导管内,呈单房或多房囊性结构,囊壁纤维化,囊内局部见质软、乳头状肿物;瘤细胞立方形,胞质丰富,嗜酸性、颗粒状。免疫组化:Syn和CgA(-),CD117(+)。结论胰腺导管内嗜酸性乳头状肿瘤为胰腺罕见肿瘤,目前除了组织学特征和K-ras基因的变化外,与胰腺导管内乳头状黏液性肿瘤很难鉴别。
Objective To investigate the clinical and histopathological features, possible etiology, diagnosis and differential diagnosis of eosinophilic papillary tumors in pancreatic duct. Methods The clinical, histopathological and immunohistochemical results of 1 eosinophilic papillary tumor in pancreatic duct were analyzed and reviewed. Results There was no gender difference in the occurrence of tumors, clinical symptoms may be manifested as upper abdominal discomfort or pain. Tumor mainly occurs in the large pancreatic duct, showing single or multiple cystic structures, cystic fibrosis, intracapsular see soft, papillary mass; tumor cells cubic, cytoplasm rich, eosinophilic, granular . Immunohistochemistry: Syn and CgA (-), CD117 (+). Conclusions Pancreatic eosinophilic papillary tumors are rare tumors in the pancreas. In addition to the histological features and K-ras gene changes, pancreatic ductal papillary mucinous tumors are difficult to identify at present.