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目的:研究血管紧张素Ⅱ1型受体(AT1R)基因A1166C的多态性与急性心肌梗死(AMI)患者冠脉病变程度的关系。方法:采用多聚酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测105例初发AMI患者的AT1R基因A1166C的多态性。对所有患者进行冠脉造影,根据结果判定冠脉病变的支数(狭窄程度≥50%)和冠脉病变的Gensini积分。结果:AMI患者中,AC+CC基因型携带者冠脉病变的支数和Gensini积分均显著高于AA基因型携带者(P<0.05)。结论:AT1R基因A1166C的多态性与AMI患者冠脉病变程度有关。
Objective: To investigate the relationship between the polymorphism of A1166C gene of angiotensin Ⅱ type 1 receptor (AT1R) gene and the severity of coronary artery disease in patients with acute myocardial infarction (AMI). Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the polymorphism of AT1R gene A1166C in 105 patients with initial AMI. Coronary angiography was performed on all patients and the number of coronary lesions (stenosis ≥50%) and Gensini scores of coronary lesions were determined based on the results. Results: In patients with AMI, the number of coronary lesions and the Gensini scores of AC + CC genotype carriers were significantly higher than those of AA genotype carriers (P <0.05). Conclusion: The polymorphism of A1166C in AT1R gene is related to the severity of coronary lesions in AMI patients.